Pharmacopeial Specifications:
- Identification: Positive for sodium and starch
- pH (1% dispersion): 5.5–7.5
- Loss on Drying: ≤10%
- Degree of Substitution: 0.2–0.4
- Microbial Limits: Complies with pharmacopeial requirements
Applications in Pharmaceutical Formulation:
Used as a superdisintegrant in tablets and capsules at 2-8% concentration. It facilitates rapid drug release by promoting disintegration in aqueous environments.
Comments:
Sodium starch glycolate is widely used due to its high swelling capacity and rapid disintegration properties. It is essential to optimize its concentration to prevent over-swelling, which may affect tablet integrity.
