Sucralfate is a white to off-white amorphous or microcrystalline powder, odorless and tasteless. It is an aluminum salt of sulfated sucrose and is practically insoluble in water and alcohol. In acidic environments (pH <4), it forms a viscous, paste-like complex that adheres to ulcer sites.
Chemical Name and CAS Registry Number:Basic aluminum sucrose sulfate [54182-58-0]
Functional Category:Antiulcer agent; gastrointestinal protectant
Identification: Positive for aluminum and sulfate
Assay (on dried basis): 98.0%–102.0%
Loss on Drying: ≤10%
pH (1% suspension): 3.5–4.5
Aluminum Content: 15.5%–18.5%
Microbial Limits: Meets pharmacopeial requirements
Used in oral suspensions and tablets for the treatment of duodenal and gastric ulcers, gastroesophageal reflux disease (GERD), and mucosal injuries.
Acts by forming a protective barrier over damaged mucosa, preventing further injury from acid, pepsin, and bile salts.
Sucralfate is non-systemic and acts locally at ulcer sites. It does not significantly alter gastric pH and has minimal drug interactions compared to traditional antacids. However, it may adsorb certain drugs (e.g., fluoroquinolones, tetracyclines), so spacing of administration is recommended.
