Microcrystalline Cellulose (MCC) Grades & Applications
| Grade | LOD (%) | Bulk Density (g/mL) | Application | Packaging |
|---|---|---|---|---|
| MCC 105 | 1.0 – 5.0 | 0.20 – 0.30 | Fine particle size enhances tablet disintegration, improving drug release & bioavailability. | HDPE / Paper Bags |
| MCC 101 | 3.0 – 5.0 | 0.27 – 0.34 | Versatile binder, diluent, and filler used in wet granulation and direct compression. | HDPE / Paper Bags |
| MCC 103 | 1.0 – 3.0 | 0.26 – 0.34 | Used as a binder, filler, and disintegrant in tablet and capsule formulations. | HDPE / Paper Bags |
| MCC 301 | 3.0 – 5.0 | 0.34 – 0.45 | Enhances drug adsorption & absorption in tablets, capsules, granules, and pellets. | HDPE / Paper Bags |
| MCC 102 | 3.0 – 5.0 | 0.26 – 0.34 | Binder, bulking agent, and disintegrant, commonly used in direct compression. | HDPE / Paper Bags |
| MCC 112 | 0.0 – 1.5 | 0.26 – 0.34 | Low moisture content grade, ideal for moisture-sensitive formulations. | HDPE / Paper Bags |
| MCC 302 | 3.0 – 5.0 | 0.28 – 0.45 | Used as a binder, filler, and disintegrant in tablets and capsules. | HDPE / Paper Bags |
| MCC 12 | 3.0 – 5.0 | 0.26 – 0.40 | Enhances compressibility, flowability, and drug content uniformity. | HDPE / Paper Bags |
| MCC 112 | 3.0 – 5.0 | 0.31 – 0.39 | Low moisture excipient for pharmaceutical & nutraceutical applications. | HDPE / Paper Bags |
Applications in Pharmaceutical Formulation
Microcrystalline cellulose (MCC) is widely used as a binder/diluent in tablet and capsule formulations, suitable for wet granulation and direct compression. It also acts as a lubricant and disintegrant, enhancing tablet integrity and dissolution. Additionally, MCC is used in cosmetics and food products for its stabilizing and texturizing properties.
Comments
Different grades of microcrystalline cellulose (MCC) vary in particle size, moisture content, and flowability, affecting their suitability for pharmaceutical applications. Larger particles enhance flow, while low-moisture grades are ideal for moisture-sensitive formulations. High-density MCC improves tablet compression and handling.
