Epitochem

Microcrystalline Cellulose (MCC)

Microcrystalline Cellulose (MCC)

Microcrystalline Cellulose (MCC): A Multi-Functional Pharmaceutical & Nutraceutical Excipient.

Microcrystalline cellulose (MCC) is one of the most extensively used excipients across pharmaceutical, nutraceutical, food, and cosmetic industries. Recognized for its exceptional binding and diluting properties, MCC plays a vital role in the development of solid oral dosage forms such as tablets, capsules, granules, and powders

Derived through the controlled hydrolysis of cellulose, MCC is known for its excellent compressibility, making it ideal for direct compression tablet manufacturing. Its uniform particle size distribution enhances flowability, ensuring consistency in tablet weight and drug content uniformity during production. Additionally, MCC exhibits strong mechanical properties that promote tablet integrity while maintaining rapid disintegration, thereby supporting improved bioavailability and drug release.

Chemical Name and CAS Registry Number :- Cellulose [9004-34-6]

Functional Category :- Adsorbent; suspending agent; tablet and capsule diluent; tablet disintegrant.

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Microcrystalline Cellulose (MCC) Grades & Applications

Grade LOD (%) Bulk Density (g/mL) Application Packaging
MCC 105 1.0 – 5.0 0.20 – 0.30 Fine particle size enhances tablet disintegration, improving drug release & bioavailability. HDPE / Paper Bags
MCC 101 3.0 – 5.0 0.27 – 0.34 Versatile binder, diluent, and filler used in wet granulation and direct compression. HDPE / Paper Bags
MCC 103 1.0 – 3.0 0.26 – 0.34 Used as a binder, filler, and disintegrant in tablet and capsule formulations. HDPE / Paper Bags
MCC 301 3.0 – 5.0 0.34 – 0.45 Enhances drug adsorption & absorption in tablets, capsules, granules, and pellets. HDPE / Paper Bags
MCC 102 3.0 – 5.0 0.26 – 0.34 Binder, bulking agent, and disintegrant, commonly used in direct compression. HDPE / Paper Bags
MCC 112 0.0 – 1.5 0.26 – 0.34 Low moisture content grade, ideal for moisture-sensitive formulations. HDPE / Paper Bags
MCC 302 3.0 – 5.0 0.28 – 0.45 Used as a binder, filler, and disintegrant in tablets and capsules. HDPE / Paper Bags
MCC 12 3.0 – 5.0 0.26 – 0.40 Enhances compressibility, flowability, and drug content uniformity. HDPE / Paper Bags
MCC 112 3.0 – 5.0 0.31 – 0.39 Low moisture excipient for pharmaceutical & nutraceutical applications. HDPE / Paper Bags

Applications in Pharmaceutical Formulation

Microcrystalline cellulose (MCC) is widely used as a binder/diluent in tablet and capsule formulations, suitable for wet granulation and direct compression. It also acts as a lubricant and disintegrant, enhancing tablet integrity and dissolution. Additionally, MCC is used in cosmetics and food products for its stabilizing and texturizing properties.

Comments

Different grades of microcrystalline cellulose (MCC) vary in particle size, moisture content, and flowability, affecting their suitability for pharmaceutical applications. Larger particles enhance flow, while low-moisture grades are ideal for moisture-sensitive formulations. High-density MCC improves tablet compression and handling.

 

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