Silicified microcrystalline cellulose (SMCC) is a synergistic blend of microcrystalline cellulose (MCC) and colloidal silicon dioxide (2% w/w). This combination enhances flowability, compactability, and tablet strength, making it ideal for direct compression formulations. For more details, refer to Cellulose, Microcrystalline and Colloidal Silicon Dioxide.
Chemical Name and CAS Registry Number :-Cellulose [CAS: 9004-34-6]
Functional Category :- Tablet and capsule diluent.
| Grade | LOD% | Bulk Density (g/cc) | Main Application |
|---|---|---|---|
| SMCC 50 | 3.0–5.0 | 0.27–0.35 | Fine standard SMCC grade with excellent flow and consolidation properties. Best disintegration time and superior binding performance. |
| SMCC 90 | 3.0–5.0 | 0.25–0.38 | Balanced flow and compaction properties. Ideal for high production speeds and rapid formulation development. |
| SMCC 90 HD | 3.0–5.0 | 0.35–0.50 | Higher bulk density and improved flow. Best suited for high-speed tableting and processing high-density actives with uniform tablet weight. |
Silicified microcrystalline cellulose is a filler used in capsule and tablet formulations. It offers enhanced compaction properties in both wet granulation and direct compression compared to conventional microcrystalline cellulose. Specifically developed to prevent the loss of compaction after wet granulation, it ensures better tablet integrity and manufacturing efficiency.
Silicified microcrystalline cellulose offers superior tensile strength and requires lower compression pressure compared to standard microcrystalline cellulose. It retains compactability even after wet granulation, resulting in stiffer compacts that demand more energy for tensile failure, enhancing tablet durability and manufacturing efficiency.
