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Hydroxypropyl Methylcellulose (HPMC)

Hydroxypropyl Methylcellulose (HPMC)

Hydroxyethylmethyl cellulose is a water-soluble polymer used as an excipient in pharmaceutical formulations. It enhances solubility, stability, and viscosity, making it ideal for oral tablets, suspensions, and topical gels. Its hydroxyethyl groups improve water solubility and salt tolerance compared to methylcellulose.

Chemical Name and CAS Registry Number :- Hydroxyethylmethylcellulose [9032-42-2]
Functional Category :- Coating agent; suspending agent; tablet binder; thickening  agent; viscosity-increasing agent.

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Pharmacopeial Specification Table for Hydroxypropyl Methylcellulose

Test PhEur 2005
Identification ✓
Appearance of solution ✓
pH 5.5–8.0
Apparent viscosity ✓
Chlorides ≤0.5%
Heavy metals ≤20 ppm
Loss on drying ≤10.0%
Sulfated ash ≤1.0%

Applications in Pharmaceutical Formulation or Technology

Hydroxyethylmethyl cellulose is used in oral tablets, suspensions, and topical gels. It has properties similar to methylcellulose but offers better water solubility, salt tolerance, and a higher coagulation temperature.

Comments

Hydroxyethyl cellulose has limited use in foodstuffs compared to its extensive application as an excipient in oral pharmaceutical formulations.

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