Ferric citrate is a reddish-brown, odorless, slightly hygroscopic powder consisting of ferric ions complexed with citrate anions. It is sparingly soluble in water and forms stable complexes in solution.
Chemical Name and CAS Registry Number: Iron(III) citrate [3522-50-7]
Functional Category: Iron supplement; phosphate binder; hematinic
Iron Content: 16.5–21%
Identification: Positive for iron and citrate
Loss on Drying: ≤12%
Solubility: Sparingly soluble in water
Microbial Limits: Conforms to pharmacopeial requirements
Used orally to treat iron deficiency anemia, particularly in patients with chronic kidney disease (CKD). It also serves as a phosphate binder to reduce serum phosphate levels in CKD patients on dialysis.
Ferric citrate offers dual therapeutic benefits as both an iron supplement and a phosphate binder. Its good tolerability profile and mild gastrointestinal side effects make it suitable for long-term use in CKD patients. However, its relatively low iron bioavailability may require dose adjustment based on therapeutic need.
