Pharmacopeial Specifications:
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Iron Content: 16.5–21%
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Identification: Positive for iron and citrate
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Loss on Drying: ≤12%
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Solubility: Sparingly soluble in water
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Microbial Limits: Conforms to pharmacopeial requirements
Applications in Pharmaceutical Formulation:
Used orally to treat iron deficiency anemia, particularly in patients with chronic kidney disease (CKD). It also serves as a phosphate binder to reduce serum phosphate levels in CKD patients on dialysis.
Comments:
Ferric citrate offers dual therapeutic benefits as both an iron supplement and a phosphate binder. Its good tolerability profile and mild gastrointestinal side effects make it suitable for long-term use in CKD patients. However, its relatively low iron bioavailability may require dose adjustment based on therapeutic need.
