Epitochem

Calcium Citrate Maleate

Calcium Citrate Maleate

Calcium Citrate Maleate is a water-soluble calcium supplement that provides a bioavailable source of calcium. It appears as a white or off-white powder and is a complex of calcium, citric acid, and maleic acid. It is commonly used in pharmaceutical, nutraceutical, and food applications due to its superior absorption compared to other calcium salts. Calcium Citrate Maleate is highly soluble in water, making it suitable for liquid and solid dosage forms.

Chemical Name and CAS Registry Number:- Calcium citrate maleate [142606-53-9]

Functional Category :- Calcium source; nutritional supplement

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Pharmacopeial Specifications

Test Specification
Identification Positive
Calcium Content 18–26%
Loss on Drying ≤14%
Solubility Soluble in water
Heavy Metals ≤10 ppm
pH (1% solution) 6.0–8.0

Applications in Pharmaceutical Formulation

  • Calcium Supplement: Used in tablets, capsules, and liquid formulations to prevent and treat calcium deficiency.

  • Fortification: Added to foods and beverages to enhance calcium content, especially in dairy alternatives.

  • Effervescent Formulations: Used in effervescent tablets and powders due to its high solubility.

Comments

Calcium Citrate Maleate is preferred over calcium carbonate due to its better absorption, even in individuals with low stomach acid. It does not cause gastrointestinal discomfort like some other calcium salts. It is widely used in dietary supplements and fortified foods.

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