Epitochem

Cellulose Acetate (CA)

Cellulose Acetate (CA)

Cellulose acetate is a cellulose derivative in which hydroxyl groups are acetylated to varying degrees. It is widely used in pharmaceutical formulations for controlled drug release, taste masking, and film coating applications. Its versatility makes it suitable for sustained-release tablets, transdermal drug delivery systems, and microparticle formulations.

Chemical Name and CAS Registry Number :-Cellulose acetate [9004-35-7]
Functional Category :-Coating agent; extended release agent; tablet and capsule diluent.

Request for the quote

Pharmacopeial Specifications for Cellulose Acetate

Test PhEur 2005 USPNF 23
Identification ✓ ✓
Loss on Drying ≤5.0% ≤5.0%
Residue on Ignition ≤0.1% ≤0.1%
Free Acid ≤0.1% ≤0.1%
Heavy Metals ≤10 ppm ≤0.001%
Microbial Limits (CFU/g) ≤10³ (aerobic), ≤10² (fungi/yeast) —
Organic Volatile Impurities — ✓
Acetyl Group Assay 29.0–44.8% 29.0–44.8%

Applications in Pharmaceutical Formulation or Technology

Cellulose acetate is used in sustained-release drug delivery, taste masking, and film coatings.
It serves as a semipermeable membrane in osmotic pump tablets and implants, enabling controlled drug release.
Additionally, it is used in transdermal patches, microparticles, and extended-release tablet matrices.

Comment

Cellulose acetate is widely utilized for controlled drug release, but formulation parameters such as plasticizer content
and active-to-polymer ratio should be carefully optimized to achieve the desired release profile.
Additionally, potential interactions with active ingredients should be evaluated to ensure stability and efficacy.

Related products